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You can take it with or without food. Should bactrim be taken with or without food. They also found that dietary fat improved survival of the bacteria. The facts The Prescribing Information for trazodone immediate-release notes that when it is taken after food, there may be: – An increase in the amount of trazodone absorbed – A decrease in the maximum plasma. It is considered a complete regime in one pill. Researchers sought to end the confusion by studying the impact of taking probiotics before, with and after meals. It is more important that the Bactrim be taken about 12 hours apart, and it is not necessary to schedule meals to accommodate that schedule Oct 31, · Take with or without food. You'll usually take trimethoprim twice a day to treat an infection, once in the morning and once in the evening. If you are able to take it without stomach upset, though, feel free to take it on an empty stomach. Do not take 2 doses at the same. 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